Reverse Vaccinology

Reverse Vaccinology

Reverse vaccinology focuses on identifying potential vaccine candidates from the perspective of the entire pathogenic genome. In 2000, Rino Rappuoli and colleges first used reverse vaccinology to screen the Group B meningococcus genome and developed the MenB vaccine. With the improvement of sequencing techniques, the integration of organism databases, and the development of many useful bioinformatics tools, reverse vaccinology has been successful in discovering previously unknown antigens and accelerating the development of vaccines.