malaria

Association of a novel mutation in the *Plasmodium falciparum* chloroquine resistance transporter with decreased piperaquine sensitivity

Background: Amplified copy number in the plasmepsin II/III genes within *Plasmodium falciparum* has been associated with decreased sensitivity to piperaquine. To examine this association and test whether additional loci might also contribute, we …

Independent emergence of artemisinin resistance mutations among *Plasmodium falciparum* in Southeast Asia

BACKGROUND: The emergence of artemisinin-resistant *Plasmodium falciparum* in Southeast Asia threatens malaria treatment efficacy. Mutations in a kelch protein encoded on *P. falciparum* chromosome 13 (K13) have been associated with resistance in …