Antisense oligonucleotides (ASO) are a class of drug molecules that are made of short nucleotide sequences (DNA or RNA) which can bind to RNA and alter its function. Some modifications that are made during the synthesis of these drug molecules can introduce different chemical configurations which in turn affect its pharmacokinetics.
This project aims at understanding the diastereomeric composition of antisense oligonucleotide drug products through investigating how different synthesis processes affect the chemical composition of the drug.